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Exact(17)
I don't know, and judging by the dosing recommendation document Health Canada has produced, neither do they, really.
Treatment in a North-European NICU was the only factor independently associated with a lower likelihood of major deviations from BNFC dosing recommendation.> In a Europe-wide study looking at the antibiotic dosing in neonates at the individual level, we have demonstrated extremely wide and non-random variations in dosing of the most frequently used antibiotics.
a – multiple daily dosing recommendation regimen is given in parenthesis; for gentamicin multiple daily dosing regimen recommendations are for PMA limits <29 weeks; 29 35 weeks and >35 weeks and have been adjusted accordingly.
e – please note, that in contrast to gentamicin and vancomycin dosing based on PMA, current amikacin dosing recommendation is based on PNA.
Secondary objectives included determination of dose-limiting toxicities (DLTs) and a dosing recommendation for a phase II trial involving administration of CPT-11 plus gefitinib.
We therefore performed a study in this patient population in order to investigate comprehensively the population pharmacokinetics and pharmacokinetics-toxicity relationships of high-dose carboplatin, resulting in an individualised dosing recommendation.
Similar(43)
Rational dosing recommendations based on mathematical considerations are increasingly being adopted in the process of drug development and use.
The reported dose was within dosing recommendations in only four of these 28 cases.
For many medicinal products, dosing recommendations for children are based on extrapolation of results from adults.
Yet, dosing recommendations based on individual AAG levels are not available.
However, a lack of well-designed and controlled trials precludes specific dosing recommendations.
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