Exact(2)
PAG can self-assemble into micelles as amphiphilic block copolymers, which exhibits an excellent loading ability for the co-delivery of docetaxel (DTX) and MMP-9 shRNA with adjustable dosing ratios.
To evaluate if 60-day and/or 90-day redosing was associated with altered pyronaridine pharmacokinetics, the 90% confidence intervals for the second dosing-to-first dosing ratios of the geometric means were computed for all pyronaridine exposure parameters (AUC0- t, AUC0-τ, AUC0 ∞, Cmax, and Ctrough).
Similar(58)
It has the added value to enable calculation of tumor-to-RBM dose ratios.
Simulation of 90Y doses was performed (matched pair dosimetry) for comparison with the 177Lu tumor-to-RBM dose ratios.
Tumor-to-RBM dose ratios would increase by 25% on average when treating with 90Y instead of 177Lu.
Tumor-to-RBM dose ratios were calculated and compared for 177Lu-based pretargeted RIT and simulated pretargeted RIT with 90Y.
However, because not all combinations or dose ratios lead to enhanced analgesia or reduced adverse events (AEs), each combination and dose ratio must be evaluated individually in carefully designed preclinical and clinical trials.
With AUC, bioequivalence of test and reference formulations was demonstrated with 1 : 1, 2 : 1 and 3 : 1 test to reference dose ratios.
And we found that the dose ratios of 2 compounds for maximal synergism were nearly the same with the ratio between each EC50.
Five dose ratios of γFe2O3 NPs were adopted in this study, which were 3, 10, 30, 100, and 300 μg/ml.
A systematic search of published literature from 1966 to September 1999 was conducted to critically appraise the emerging evidence on equianalgesic dose ratios derived from studies of chronic opioid administration.
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