Unlike other pediatric dosing systems, our model provides active dosing assistance and dosing process management, not just static dosing advice.
Commercial CPOE systems, including Horizon Expert Orders, often use formulary references such as First Databank [ 31] or Lexicon-Multum [ 32] for static dosing advice (e.g., drug-drug interactions or allergy alerts) but not for active dosing assistance or management of the dosing process where tailored doses are suggested based on the patient's clinical profile.
In addition, we performed a separate simulation study using dose process as estimated from the data [ 13].
Emergency drugs, parenteral nutrition and drugs prescribed as needed were not observed as the delivery of these medications did not follow the unit-dose process described above.
Campaign Dose: Process evaluation is conducted in each intervention town to collect data on the amount of media exposure achieved, number of campaign resources distributed, number of partnerships established, and number of presentations, events and other activities carried out by campaign staff to promote the campaign messages.
Conolly and Lutz (2004) provided concrete examples of the potential for misinterpretation when multiple low-dose processes are superimposed on each other in the intact organism.
Cetuximab is also dosed below the MTD, whereas erlotinib has followed a conventional cytotoxic dose-selection process, with dosing at the MTD.
During the dose optimization process the dose constraints were adjusted to obtain adequate and homogeneous target volume coverage while minimizing dose in heart, spinal cord, and both lungs.
In the dose calculation process, the target dose was deduced from the diode reading with the application of a proper calibration factor (Fcal) which is corrected with OAWCF d [4].
Indeed, this variability in losoxantrone clearance contributed to the unsuccessful utilization of pharmacokinetically guided dose escalation in the dose escalation process in the single agent phase I studies (Graham et al, 1992).
This registry permits facilities to compare dose levels to national benchmarks, helps standardize the dose reporting process, and may potentially alert a facility when a threshold dose has been exceeded.
