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3) Assessment of morphine potency using a within-subjects cumulative dosing procedure resulted in lower ED50 values compared to data collected using a between-subjects design (hot plate: 2.6 vs 4.9; tail withdrawal: 2.6-2.9 2.6-2.9mg/kg).
The present study was designed to determine the extent to which D2/3 receptor activation and blockade can modulate morphine-induced locomotion using a novel cumulative dosing procedure in Swiss Webster mice.
During a feasibility study carried out in December 2005, where we submitted three animals to the DLW dosing procedure (these animals were later tested in March 2006), a third point was measured at 3-h post-DLW injection.
Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses.
The dosing procedure required was 10 to 15 seconds per animal.
Additional details of the lead dosing procedure have been reported elsewhere (Lasky et al. 2001b).
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Alternative dosing procedures should be investigated, and process blank preparation and biotesting should be standardized.
We first expose zebrafish to ethanol chronically using a dose escalation procedure in which fish are kept in a final concentration of 0.5% vol/vol ethanol for 10 days while control fish receive identical dosing procedures but no ethanol.
The findings from these clinical pharmacology studies are synthesized and presented in a framework designed to (1) inform clinicians about the advantages and disadvantages of buprenorphine as an opioid maintenance agent, and (2) provide information about dosing procedures that may optimize the use of buprenorphine in the clinic.
Antimicrobial dosing, procedures, residual colonization, antimicrobial timing were not always reported and therefore not considered in the outcome analysis.
This sex difference in PBDE-47 body burdens corresponds to a previous study using similar dosing procedures with this species (Muirhead et al. 2006).
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