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Avalanching effects and oscillating mass flow rates in conveyors lead to feeding and dosing problems.
And a nongeneric alternative, Sanofi's Auvi-Q, was pulled from the market last year because of dosing problems.
Farmers could simply pour one packet into 20 liters of water in the backpacks they used to spray their fields, eliminating dosing problems and waste.
Ranitidine was the most implicated drug for dosing problems.
Also, there were significant associations between renal impairment and drug choice problems (p = 0.029) or dosing problems (p = 0.027).
In some studies dealing with dosing problems, questionnaires [ 13], quizzes or chart reviews were usually adopted in research methods.
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In clinically successful DBS applications, such as Parkinson disease, the dosing problem can be solved by trial and error.
"There's a concern that if you were to give the patient the cream to take home, they'd just keep putting more and more and more on, and you'd have a dosing problem," Dr. Kinney said.
Hence, with an oral bioavailability of about 40% [9], the weight-adjusted dose used in the animal experiment was many times higher than the human dose, making it unlikely that a dosing problem was the reason for the negative results.
In this study, excessive dosage was the most frequent dosing problem.
Renal impairment was associated with both the drug choice problem (p = 0.029) and the dosing problem (p = 0.027).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com