Exact(5)
"There's a concern that if you were to give the patient the cream to take home, they'd just keep putting more and more and more on, and you'd have a dosing problem," Dr. Kinney said.
Hence, with an oral bioavailability of about 40% [9], the weight-adjusted dose used in the animal experiment was many times higher than the human dose, making it unlikely that a dosing problem was the reason for the negative results.
In this study, excessive dosage was the most frequent dosing problem.
Renal impairment was associated with both the drug choice problem (p = 0.029) and the dosing problem (p = 0.027).
Thus, injecting AuNPs intratumorally solves the dosing problem, but a system to transport the AuNPs throughout the tumor mass is needed.
Similar(55)
Avalanching effects and oscillating mass flow rates in conveyors lead to feeding and dosing problems.
Ranitidine was the most implicated drug for dosing problems.
Also, there were significant associations between renal impairment and drug choice problems (p = 0.029) or dosing problems (p = 0.027).
In some studies dealing with dosing problems, questionnaires [ 13], quizzes or chart reviews were usually adopted in research methods.
When matching the cause to the problem, inappropriate drug or dose selection was found to be the most common cause for drug choice problems and dosing problems.
The most common DRPs were "others" (i.e., insufficient awareness of health and diseases), drug choice problems, dosing problems, and drug interactions.
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