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In contrast, a moderate dosing policy is preferred when the DR strain is a fit enough competitor that acquisition of resistance plays a sufficiently small role in the DR population dynamics.
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Fifth, a one-dose policy was recommended.
All three groups had a high dose policy.
15 25 Therefore, the Expanded Programme on Immunization (EPI) recommended a one-dose policy.
The main argument advanced for a one-dose policy was that compliance with the second dose was too low.
57 The studies indicate that a two-dose policy providing the first dose of MV before 9 months of age is associated with major reductions in child mortality compared with the current one dose at 9-month policy.
Once again, if a single-dose policy were to be universally accepted annual savings would fall to £321,993 driving the threshold royalty fee to £6.35.
Table 3 shows the number of additional sensitisations predicted in England and Wales at different NIPD test sensitivity levels for a two-dose policy.
Two MMR vaccine doses provide 66%95%% effectiveness against mumps (22, 23 ), and the 2-dose policy has reduced mumps incidence by >99% compared with incidence during the prevaccine era (24 ).
The aim of the present study was to estimate the cost savings (if any) in England and Wales for two implementation strategies compared to the current two-dose RAADP programme (and a possible future single-dose policy).
In making this analysis of the effect of only one dose of MV, 6 8 the EPI assumed that a two-dose policy was not feasible or unjustified (assumption 6).
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