Sentence examples for dosing paradigm from inspiring English sources
The choice of dosing paradigm is a challenge.
Altogether, these data suggest that the selected dose levels and twice a day dosing paradigm were appropriate to test efficacy and safety in ischemia models.
Mice with a null mutation of COX gene have been a useful tool for investigating the role of each COX isoform in both physiological and pathological conditions in the CNS by overcoming the complexity of dosing paradigm, duration of treatment, and possible unspecific inhibition of both COX isoform [ 31].
Since these developmental changes are non-linear dynamic processes, this dosing paradigm may result in under- or over-dosing, particularly in specific age groups.
It was not clear whether the same dosing paradigm would be optimum for an engineered form of Filgrastim with substantially altered pharmacokinetics.
This phase II dose-ranging study was designed to assess whether the prostaglandin D2 receptor 1 antagonist laropiprant (LRPT; MK-0524) would (1) reduce extended-release niacin (ERN induced flushing in dyslipidemic patients and (2) support a novel accelerated ERN dosing paradigm: initiating ERN at 1 g and advancing rapidly to 2 g.
The toxicity of AFM was studied in rats using single dosing and multiple dosing paradigms.
We provide an important quantitative and statistical framework for designing CreERT-based experiments and choosing tamoxifen dosing paradigms.
To evaluate the efficacy of different dosing paradigms of PF-04523655 (PF) versus ranibizumab (comparator) in subjects with neovascular age-related macular degeneration (AMD).
Since some patients may undergo [18 F]AFM PET imaging more than once during a short period of time (e.g., within 1 or 2 weeks), we used both single and multiple dosing paradigms in the rat toxicity study.
In early in vivo studies, PHA-408 demonstrated efficacy at high doses; however, the correlation between PHA-408 exposure and efficacy could not be established using standard dosing paradigms for the rat disease models.
