Sentence examples for dosing note from inspiring English sources

However, as discussed above, it is not known how much of this increase might have been due to increased BBB permeability and how much might have stemmed from a possible build-up in plasma VGB concentration with repeated dosing (note that we measured plasma VGB only after the first dose).

• Are your X-ray examinations and doses noted in your record?

All six patients on maintenance doses noted inhibition of further outbreaks of infection.

The significance of the single observations of palpitations (noted with velusetrag at 30 mg) and asymptomatic junctional escape rhythm (with 50 mg dose) noted in the pharmacodynamic transit study 2010 is uncertain, considering the limited number of subjects.

Of note, dosing mismatch was the only area in clinical drug development that has significantly improved between 1995 and 2004 likely as a consequence of improved pharmacometric modeling and simulation.

The in vivo toxicology tests must be performed in compliance with Good Laboratory Practice (GLP), interspecies scaling (allometric scaling) should be applied to calculate from animal to human dose [Note for guidance on non-clinical safety studies for the conduct of human clinical trials and marketing authorization for pharmaceuticals, CPMP/ICH/286/95, European Medicines Agency].

The 15 mg/m 10-day dosing was noted to be optimal, with responses observed in 65% of patients.

Likewise, the significant difference in dosing requirements noted between Caucasians and non-Caucasians with both tacrolimus preparations raises interesting mechanistic hypotheses worthy of further study such as ethnic differences in CYP3A5 genotypes [ 14].

Patients who did not return their blister cards at monthly study visits were conservatively regarded as taking >125% of scheduled doses; we note that some subjects may have had difficulty returning cards due to illness-related factors.

[Note: Bacterial doses corresponding to 10-10 CFU/ml were tried for inducing acute lung infection after intranasal administration or septicemia after intraperitoneal administration.

Calabrese and Baldwin (2003a) also evaluated data from NTP dose-ranging studies and noted these have the advantage, among other things, of using five dosing points per testing.