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The dates of treatment initiation and discontinuation, initial dosing, dates and reasons for treatment interruptions and treatment changes, dosing modifications, and follow-up tumor assessments were also recorded.
Other treatment-related data collected included dates of treatment initiation and discontinuation, initial dosing, dates and reasons of treatment interruptions and treatment changes, dosing modifications and follow-up tumor assessments.
Steady-state dose-corrected trough plasma sunitinib concentrations were derived using data from patients who had taken sunitinib for ≥ 10 consecutive days by correcting observed concentrations in patients who underwent dosing modifications based on the 37.5-mg starting dose (starting dose ÷ actual dose).
Thus, appropriate dosing modifications should be applied to prevent inadequate antibiotic concentrations and therapeutic failure [5, 7, 8].
Esmolol, amiodarone, nesiritide, bumetanide, sildenafil, and prostaglandin E1 seem to require dosing modifications in children supported by ECMO, whereas it seems that hydralazine, nicardipine, furosemide, epinephrine, and dopamine can be dosed similarly to children not supported by ECMO.
Dosing modifications may also be appropriate for these patients.
Similar(47)
Dose modification criteria were defined in the protocol.
This dosing modification was associated with decreased toxicity (P = 0.024) without diminishing response.
Dose modifications were made for toxicities.
Dose modifications became necessary in the majority of patients.
Dose modifications were seldom required.
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