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Information regarding the frequency of dosing modification along with consultation of dosing compendiums and estimation of success rate in dosing guidance was acquired.
This dosing modification was associated with decreased toxicity (P = 0.024) without diminishing response.
Thus, azithromycin dosing modification is not needed in patients with kidney disease.
While close monitoring is recommended, dosing modification was not generally necessary, allowing patients to remain on crizotinib treatment.
While close monitoring is recommended, dosing modification was not generally necessary, allowing patients to continue to benefit from crizotinib treatment.
However, neither time until dose adjustment nor strategy of dosing modification was related to recovery of baseline renal function at the EOT (data not shown).
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Dosing modifications may also be appropriate for these patients.
Nine patients (38%) required dose modification.
Eleven patients (28%) discontinued study therapy due to toxicity and 17 patients (43%) required dose modification.
The dose modification factor ranged from 2.9 after 2 h incubation to 4.5 at 6 h.
Specifically reviewed were hematologic, gastrointestinal, and renal toxicities and the need for dose modification and treatment delays.
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