Sentence examples for dosing led from inspiring English sources

Systemic but not local IL13-PE dosing led to the development of neutralizing antibodies against this chimeric protein, which effectively blocked the cytotoxic action of IL13-PE in vitro toward tumor cells.

Increases over a sustained period were successfully achieved (figure 1C) and as expected multiple daily dosing led to lower variability between peak and trough concentrations.

For example, in the PC3 model, once-weekly dosing led to a TGI of 74% while twice-weekly dosing resulted in a TGI of 83%.

Both single and repeated nalmefene oral dosing led to a very high μ-OR occupancy and 50 h after administration, the occupancy was still ∼50% while plasma concentrations were negligible.

A recent study evaluating efficacy and adherence of once daily versus 3 times daily dosing of Asacol® showed that once daily dosing led to reduced relapse rate, mainly due to improved adherence [ 3].

Etoricoxib has demonstrated to be highly bound to plasma proteins [ 16], and central nervous system penetration has been shown in a study in hip surgery where oral etoricoxib dosing led to meaningful concentrations in cerebrospinal fluid [ 17].

Optimum antiangiogenic drug dosing leads to normalization of blood vessels and better therapeutic management of solid tumors.

Limited data suggest the PK of itraconazole are non-linear and highly variable, and that weight-based dosing leads to sub-therapeutic dosing in smaller children [93,94].

However, there is evidence that multiple dosing leads to problems with adherence especially during the school day where children receiving medication may feel stigmatised by their classmates [ 5].

When the F.D.A. approved it in December 1992, its price of $986 a dose led to Congressional hearings.

In men, the cocaine dose led to a 20% drop in the volume of blood passing through the brain.