Sentence examples for dosing issue from inspiring English sources
Analysts had expected Teva to alter its autoinjector's design to remedy a dosing issue cited by the FDA, but Olaffson said the company was not planning any modifications to its device at this point.
Possibly as a result of this dosing issue several meta-analyses have found the incidence of death to be greater for tigecycline compared to the comparator antibiotics, this was most evident in the nosocomial pneumonia studies [ 91– 91].
But he added, "The fact remains that our V.A. staff self-discovered these potential dosing issues almost two years ago, closed the program, self-reported to the N.R.C., cooperated fully with multiple investigations and have been transparent throughout the entire process".
For colistin, as a very "old" agent, are dosing issues sufficiently solved?
25– 27 However, randomized controlled trials assessing optimal benefit are missing and dosing issues are still under debate.
Other dosing issues are also different for oral drugs and the argument for 'flat dosing' irrespective of body surface area, is especially strong for oral drugs.
Although some of these antidepressants may not be beneficial (like probably tricyclics), methodological considerations have been raised, among them dosing issues should be carefully evaluated.
While strain, species, and dosing issues may be responsible for this negative result, the biological responses of HSP25 and 12/15-LO 12/15-LOmin may underlie tois failure.
Pre-clinical studies have generally indicated a greater impact of PD-L1 blockade, and specific antibody properties or dosing issues may be relevant to the phase I clinical studies given the widespread distribution of PD-L1.
However, widespread use has been hampered due to severe side effects and dosing issues, and the ability of tumor cells to escape the effects of IFNs by inducing survival pathways thereby causing tumor resistance to IFN treatment.
