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As felodipine has poor and variable bioavailability, the multiple daily dosing is needed.
Felodipine, a calcium channel blocker has been widely used for the treatment of hypertension and cardiovascular diseases; but the frequent dosing is needed for its poor solubility and variable bioavailability.
Another major barrier is immunogenicity of the synthetic siRNAs or delivery vehicle, especially if repeated dosing is needed to treat disease [ 9, 10].
Exposure is negligible after 12 hours post dose, explaining why twice-daily dosing is needed in order to obtain full effect on glycemic control.
However, additional research investigating specific kidney histochemistry and physiology in response to 2A-DNT dosing is needed to validate such hypotheses as presented herein.
Given the importance of flexible insulin regimens to the management of type 1 diabetes in children, an objective measure of knowledge regarding carbohydrate counting and insulin dosing is needed.
Similar(54)
Continue induction dosing was needed until viracemia disappearance.
Typically, decreased insulin dosing was needed in the one to two days prior to delivery.
Data evaluating guideline-recommended weight-based vancomycin dosing are needed to confirm the efficacy of this approach versus lower traditional dosing.
How big a dose is needed and where it is injected are questions for the trials, the doctors said.
The youngest age at which the vaccines can be given is six months, though revaccination (with two doses) is needed later.
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