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dosing is expected to cause a decrease in HbA1c level from baseline as comparable with that of sulfonylureas (0.9 2%) and potentially greater than that of DPP-4 inhibitors.
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An adult dose is expected to cost more than $4 a pill, meaning $28 or more a week.
At these depths the radiation dose is expected to be 500 and 40 rads/year, respectively.
Treatment with 12 doses instead of 270 doses is expected to be a clear success.
Class IV compounds, which have low membrane permeability as well as poor aqueous solubility, are often poor candidates for development, unless the dose is expected to be low.
If the dose to any part of the extremities of a worker is likely to exceed three tenths of the annual dose limit, an additional dosimeter should be placed on the part of the extremity where the dose is expected to have its highest value.
The aim of this study was to determine which radionuclide is capable of reaching tumour-sterilizing absorbed radiation doses to the tumour of at least 60 Gy, as such a dose is expected to lead to a high probability of tumour cure over a wide range of tumour sizes according to the linear-quadratic (LQ) model (from 1 to 500 mm3) [3],[6].
Therefore, the 840 mg q3w pertuzumab dose is expected to provide greater treatment benefit than the 840/420 mg dose in patients with HER2-positive aGC.
Instead of responding to the expression change caused by dose reduction, this system responds a priori in the sex where the X chromosome dose is expected to be one [ 21].
Furthermore, paclitaxel given every week at a lower dose is expected to exert an antiangiogenic effect [27] and has already been demonstrated to improve response and survival in phase III trials for breast cancer [28], [29].
ZD6474 doses of 100−300 mg day−1 were selected for the phase II studies, as these doses are known to be well tolerated and pharmacokinetic data from phase I evaluation indicate that even the 100 mg dose is expected to yield biologically active systemic concentrations of ZD6474.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com