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"Dosing is by trial and error," Dr. Jafri says.
Researchers have shown that twice-daily dosing is about the maximum frequency most patients can handle.
They maintain that they acted in good faith and indeed, chemotherapy dosing is both science and art.
Atazanavir's once-daily dosing is more convenient than that of rival protease inhibitors, one of the most potent classes of AIDS drugs.
Without it, more frequent and higher dosing is often implemented, resulting in poorly controlled asthma.
Repeated dosing is preferable to avoid complete tumour receptor saturation.
Intravenous dosing is recommended in those patients with ICH.
However oral dosing is the preferred route clinically.
Given the many practical advantages, fixed dosing is generally recommended for FIH studies with mAbs.
Chlorine dosing is less effective if pH levels are over 8.5 (Macomber 2001).
Lastly, it may be that prolonged dosing is required for an effect [10].
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CEO of Professional Science Editing for Scientists @ prosciediting.com