Use of nonstandardized dosing instruments and lack of knowledge that dosing is weight-based contribute to dosing errors.
They also emphasised the importance of always providing patients or caregivers with the appropriate dosing instruments (ie, cups, syringes) if an unfamiliar term like mL was included on the Rx label.
The aim of this study is to explore whether the WHO praziquantel pole is a satisfactory dose instrument for mass treatment of S. haematobium.
The aim of this study is to explore in both theory and practice whether the WHO praziquantel pole is a satisfactory dose instrument for mass treatment of S. haematobium, or whether some other approach could be more appropriate in order to avoid under- and overdosage.
The overall agreement was fair to good (kappa = 0.679; 95% CI, 0.569 0.790), and 21/118 (17.8%) INR measurements showed a difference in dosing decision between the two instruments (Table 1).
Exact comparisons of findings from various groups are difficult because different types of cigarettes (reference compared with commercial), doses of cigarettes, instruments, exposure protocols and a wide variety of mouse strains are used.
The suspension was inserted inside the reactors by means of dosing pumps (Hanna Instruments, model BL20).
Under most realistic scenarios, dose estimation is more complex than directly using instrument readings because dose estimates need to be supplemented with data on the environmental radiation field and foodstuffs as well as information on the ways in which persons were exposed.
Radiochemical conversions and purities were determined by radio-HPLC using beta-sensitive detectors and dose-calibrators (Veenstra Instruments) and by radio-TLC using Cyclone phosphor storage screens (multisensitive, Packard) and OptiQuant software.
