Sentence examples for dosing in the next from inspiring English sources

There was a minimum of at least 7 days between completion of dosing in one group and start of dosing in the next group to allow a satisfactory review of the safety and PK data from lower dose levels prior to progression to the next higher dose level [ 21].Six single oral dose levels of SMT19969 (2 to 2000 mg) or placebo were studied (Table  1).

That is, if a small FIP study returns an estimate of ED50 within twofold of the truth, doses selected in the next stage of development (Phase 2 dose-ranging) are likely to efficiently deliver a refined estimate of ED50.

Therefore, the effects of heparins should be examined in lower doses in the next step.

Intravenous antibiotics were given at induction of anaesthesia, with two further doses in the next 24 h.

If these complications developed after docetaxel dose adjustment, the S-1 dose in the next cycle was reduced by 20%.

If peripheral neuropathy persisted between two following cycles, the oxaliplatin dose in the next cycle had to reduced by 50%.

If diarrhea of grade ≥3 persisted despite atropine or loperamide use, the irinotecan dose in the next cycle was reduced by 20%.

The starting dose was 10 mg TAK-438 and the decision to proceed to the next dose in the next cohort was made after review of blinded safety and pharmacokinetic data from the preceding cohort.

Pandemic planners may consider initially administering a single dose of adjuvanted pandemic vaccine to allow higher population coverage from limited dose supply, followed by a booster dose in the next season if the same strain is circulating.

If pain persisted between two following cycles, oxaliplatin dose in the next cycle had to be reduced by 40% Treatment withdrawal was planned in the case of persistent neuropathy with pain (G3) after the dose reduction.

If any toxicity applicable to Table S2 occurred, the dose of each drug in the next administration was to be decreased according to Table S3.