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Modifications of dosing in response to ALT/AST elevations as per-protocol, led to normalisation/improvement in the majority of patients, with more methotrexate patients (four) than tocilizumab patients (one) discontinuing owing to these elevations.
In respect to drug prescription, elevated serum creatinine concentrations regularly trigger dose reduction for renally excreted drugs, although the converse-increasing drug dosing in response to low serum values-is infrequently considered in clinical practice.
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In line with these concerns, our study has been directed to quantify the changes in antioxidant status and color indices of blackberry jam obtained with different types of pectin (degree of esterification: DE, degree of amidation: DA) and doses in response to processing and storage for 1, 3 and 6 months at 20°C.
BIS monitoring was initiated at the onset of TH, and neuromuscular blockade (NMB) was dosed in response to shivering.
Anemia management guidelines and protocols thus require appropriate adjustment of erythropoiesis-stimulating agent (ESA) doses in response to Hb deviations relative to the target range.
Whether clinicians should decrease the warfarin dose in response to a mild, asymptomatic elevation in the international normalized ratio (INR) is unknown.
This observation is particularly interesting in that others have noted a strong correlation between maximum prescribed dose of phenytoin or carbemazepine in epilepsy and genetic variants in CYP2C9 or SCN1A, suggesting clinical adjustment of dose in response to genotype [44].
How should we modify the dose in response to altered renal drug clearance and in those requiring RRT?
Smokers are also advised to use extra pieces between doses in response to episodes of acute craving.
43 44 In these studies, however, participants reduced their drug dose in response to the lower blood pressure reading at home.
First, individual patient variability mandates dynamic and frequent changes in drug selection and dose in response to changing clinical situations [ 2, 3].
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