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It is clear that the presence of several therapeutic hairpin species will require careful dosing in order to achieve the desired levels of silencing.
Therefore it may be necessary to re-evaluate the dosage of rapamycin and the effects of cyclic dosing in order to see stronger effects.
While no prior studies have examined the effect of ceftriaxone dosing in order to determine study power, prior studies of ceftriaxone for SBP may be instructive.
The need for wide-ranging individual GH dosing in order to promote growth has previously been demonstrated during prepuberty [ 28], here we find similar requirements when studying IGFs and growth during the pubertal period.
Clinical and biochemical evaluations were performed before starting the treatment and then monthly throughout the treatment (hemogram, AST, ALT, gama-GT, TSH and free T4 dosing) in order to evaluate adverse events, tolerance and efficacy.
For piperaquine, amodiaquine, and lumefantrine, this requires three-day dosing in order to load sufficiently to provide therapeutic concentrations (i.e., >MIC) for long enough to eliminate all the parasites.
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More than 11% said they skipped or reduced prescription doses in order to save money.
It can be so potent that those on methadone treatment (methadone being an oral substitute for heroin) sometimes spit out their dose in order to inject it and achieve a desirable high.
In particular, why has there been such a serious resurgence in Angola and the DRC, stretching vaccine supplies to the point that consideration is being given to reducing the dose in order to cover more people – or even to offering doses of lower efficacy to larger numbers of individuals in an effort to halt transmission through an overall increase in protection?
NG dose was 1 mg/kg greater than the recommended dose in order to avoid food reduction bioavailability.
Simulations for oral dosing were performed using the 30-mg/kg oral dose in order to assess the dose frequency required to hit a range of target concentrations.
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