This is insufficiently anticipated by currently recommended dosing guidelines.
Rational dosing guidelines for drugs in pediatrics are urgently needed.
http://ctdbase.org PharmGKB Database of drug information including dosing guidelines, drug labels, signaling pathway diagrams, drug-gene associations, and drug-phenotype relationships.
As a consequence, there are no definitive dosing guidelines that can be used for all critically ill patients who undergo CRRT.
To study the adherence of rheumatologists to the hydroxychloroquine (HCQ) dosing guidelines established by the American Academy of Ophthalmology in 2011 and 2016.
Optimized dosing regimens for specific drugs may then serve as a basis to develop dosing guidelines for existing or newly developed drugs with similar disposition and/or effect.
Bioidentical compounded hormone therapy is popular among patients, but providers do not have pharmacokinetic information or dosing guidelines for these preparations.
Accordingly, the available dosing guidelines often are based on PK data obtained from healthy volunteers or noncritically ill patients, with little consideration for the sepsis-induced PK changes that may occur [13].
In 2014, the American Society for Blood and Marrow Transplantation published conditioning chemotherapy dosing guidelines for obese patients and recommended dosing of melphalan using actual body weight (ABW) in the body surface area calculation.
Based on this approach, it has been possible to develop rational dosing guidelines according to the specific characteristics of the patient for most of the drugs used in anesthesia.
Quantities of compound were converted into patient-year equivalents using WHO dosing guidelines [8].
