Exact(2)
Among partially prophylaxed infants with at least one dosing gap, an average of 56.5 days elapsed between first and second doses; 51.7 days between second and third doses; 48.0 days among third and fourth doses; 46.4 days between fourth and fifth doses; and 44.0 days between fifth and sixth doses.
An oral extended-release (ER) formulation of capecitabine was developed for twice daily dosing, theoretically providing a continuous exposure to capecitabine, thus avoiding the undesirable in-between dosing gap inherent to the dosing schedule of the marketed capecitabine immediate-release formulation (Xeloda®).
Similar(58)
On average, subjects had 1.5 dosing gaps (time between doses >35 days) with a mean gap length of 9.4 days or 44.4 days since the previous dose, suggesting that dosing gaps do not need to occur often or be lengthy to be associated with an increased risk of RSV-related hospitalization.
The majority of dosing gaps occurred before the 3rd dose, (36.8% of gaps occurred between the first and second doses; 25.5% between the second and third doses; 20.2% between third and fourth doses; 11.8% between fourth and fifth doses; 5.8% between fifth and sixth doses).
A pharmacy-dispensing analysis in which 10 390 infants who received palivizumab were evaluated showed that when palivizumab compliance was defined as dosing gaps of ≤35 d, RSVH breakthrough rates were higher in noncompliant vs. compliant infants (1.4% vs 3.1%; odds ratio, 2.2 [95% CI: 1.4, 3.5]; P < 0.001).
On average, subjects had 1.5 dosing gaps, with a mean (SD) gap of 9.4 days (11.4) or 44.4 days since prior dose.
Dosing gaps were also longer for African Americans and Hispanics compared with Caucasians, though the difference was not significant for African Americans (p= 0.063).
COPENHAGEN, 24 October 2012 - On World Polio Day, UNICEF has commended the continued contribution of industry to global polio eradication efforts, particularly in helping meet a 410 million dose gap in 2012 and preventing a 300 million dose gap in 2013.
In addition, given the potential risks and consequent global disease burden, epidemiologic studies are urgently needed to quantify the cardiovascular risks of particulate matter exposures from indoor biomass burning in developing countries, which lie in the dose gap of current evidence.
As a result, there will always be certain medications without any dosing regions or instances of dosing region gaps where the ADM is unable to suggest an appropriate dose.
TO the list of differences between men and women, we can add one more: the drug-dose gender gap.
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