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53 The approved dosing for use in Europe is an initial dose of 0.6 mg daily for one week, with a recommended titration to 1.2 mg daily after the first week.
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Dosing for all drugs used was obtained from previously published studies [22].
This study provides the first PK data in the Chinese population and is essential for designing CMS dosing regimens for use in Chinese hospitals.
Novartis said the site would produce up to 50 million doses for use in the United States.
Later, when rich nations donated 78 million doses for use in poor ones, the health agency could not deploy them because it was bogged down in negotiations with vaccine companies over liability and costs.
In this study, it was shown that the novel SV2A radiotracer [18F]UCB-H meets the standard regulations regarding radiation dose for use in human clinical trials.
This dilemma requires the prescribing physician to go beyond the limitations of the product label, often without benefit of appropriately designed clinical trials, in an attempt to select safe and effective doses for use with these smallest of patients.
Hanssen classified antibiotic-loaded bone cement into high dose (>2 g antibiotic per 40 g cement) and low dose (<2 g antibiotic per 40 g cement) and recommended high dose for use as beads or spacers and low dose for prosthesis fixation [21].
The dual-mode gadolinium liposomes could enable reduced particle dose for use in CE-MRA and increased contrast sensitivity for use in molecular imaging.
However, little is known about its pharmacokinetics and optimal dose for use.
Dose-response experiments were carried out for all MOs to determine the highest nontoxic dose for use in further experiments.
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