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In the 1-h schedule, the dose of PM00104 was escalated by increments of 100%50%0% if grade 2 toxicity occurred, and 25% if grade 3 or 4 toxicity occurred), while in the 3-h schedule, in view of the higher starting dosing, doses were escalated by increments of 25%.
Rats with adjuvant arthritis were treated at disease onset (10 days post arthritis induction) with EC0746, methotrexate (MTX), and etanercept at indicated doses, dosing routes, and dosing frequencies.
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The flow rate, duration of dosing, dose solution concentration were optimized and adjusted according to the dosage required.
After a stabilization period of daily maintenance administration, subjects received quintuple (5× daily maintenance dose) and sextuple (6× daily maintenance dose) doses every 120 h.
Various important parameters of total dose, dose rate, monomer-to-cassava starch ratio and maleic acid content were studied.
Cows that received the highest dose (Dose 4, n = 7) all showed estrus, whereas those that received the two lowest doses (Dose 0, n = 5; Dose 1, n = 6) did not.
LET spectra and radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured for the space mission with different dosimeters.
Radiation quantities (fluence, absorbed dose, dose equivalent and quality factor) were measured with passive dosimeters composed of TLDs/OSLDs and CR-39 PNTDs for the STS-114 mission.
A single-dose, dose-ascending clinical study of ISIS-SMNRx in children with Type 2/Type 3 SMA has previously been completed.
Factors potentially impacting this variability include: the choice of dose, dosing duration, assay sensitivity, statistical methodology, study population, and compliance.
Iterative reconstruction may be particularly useful in low-dose dose CT of the urinary tract where image noise is typically high.
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