Sentence examples for dosing discretion from inspiring English sources

Investigator dosing discretion was permitted by the protocol, and "individual patient circumstances" was the most commonly selected reason for not following the algorithm for basal insulin (60 80% of deviations); "fear of hypoglycemia" was the second most selected reason (10 18% of deviations).

An open-label test of dobutamine at fixed 5 mcg/kg/min or milrinone at fixed 0.25 mcg/kg/min doses (at discretion of the attending physician) will be started in patients with persistent abnormal CRT or non-achieved lactate goals, and negative FR status.

DMARDs were maintained at stable doses (choice and dose at investigator discretion); if DMARDs were poorly tolerated (as determined by the investigator), tocilizumab was administered as monotherapy without a washout period.

Twelve of the first 15 patients required dose reduction early in therapy or had dose delays for toxicity, and the protocol was subsequently amended to begin with sorafenib 400 mg once a day with the option of escalation to twice daily dosing at the discretion of the treating physician if tolerable.

Treatment-related adverse events are summarized in Table 2. Twelve of the first 15 patients required dose delays or reductions for toxicity, and the protocol was subsequently amended to begin with sorafenib 400 mg once a day with the option of escalation to twice daily dosing at the discretion of the treating physician.

The recommended phase II dose for the combination regimen was to be defined as the dose level at which dose escalation for each compound was to cease, or a lower dose, at the discretion of the Investigators.

The first dose is instilled over 8 12 hours; a second dose is given 24 hours after the start of the first dose, at the discretion of the treating physician.

Dose reduction is not permitted for mitomycin, however the dose of BCG can be permanently reduced to a third of the normal dose at the discretion of the treating clinician.

The epidural catheter was placed at Th 8/9, Th 9/10, or Th 10/11 interspace, and 0.2 0.375% ropivacaine was infused during surgery with varying doses at the discretion of the caregiving anesthesiologist.

Other medications were added or increased in dose at the discretion of the investigator.

Trimethoprim-sulfamethoxazole was started intravenously at a dose of 320 mg trimethoprim/1600 mg sulfamethoxazole twice daily and could be switched to oral treatment using the same dose at the discretion of the treating physician.