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Due to clinical dosing constraints of repeat doses of VGB being given at 12 h intervals, we were unable to obtain accurate VGB elimination pharmacokinetics from brain.
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An approach based on the dose constraints principle is chosen.
Such problems arise in the field of intensity-modulated radiation therapy when one attempts to describe physical dose constraints and equivalent uniform dose constraints within a single model.
In literature some data are available about dose constraints and volumes according to the tissue architectures.
Such problems arise in the field of intensity-modulated radiation therapy when one attempts to describe physical dose constraints and equivalent uniform dose constraints within a single model; see [4].
In conclusion, WBRT to C1 limits parotid dose, and parotid dose constraints are achievable compared with inferior border at C2.
Dose constraints of cerebral OAR used in conventional RT, radiosurgery (SRS) and stereotactic radiotherapy (SRT) are debated.
The completeness property of this method guarantees that calculated treatment plans fulfill the dose constraints given by the oncologist.
All plans met required dose constraints on all organs at risk, and all measured PTV-cord dose gradients were steeper than planned.
In this article, we propose a large review of dose constraints used for three major cerebral OAR: the brain stem, the hippocampus and the brain.
Although there are no specific dose constraints for the choroid plexuses in external beam radiotherapy, in our opinion the relatively high doses delivered to these structures would merit further consideration, especially in case of therapeutic applications of RGD peptides.
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