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The healthy subjects in this study were domiciled within the clinical unit, with the time zero for serum cortisol sampling and time of dosing being the same for all subjects.
Preliminary evidence has recently shown that these processes could be counterproductive, at least theoretically, if Tregs are also deleted or sequestered (M. von Herrath, personal communication) and that the balance of induction/deletion is strongly influenced by the dose (frequency), with more frequent dosing being more harmful (11– 11).
This concept is currently being evaluated for many 'traditional' chemotherapeutic compounds, with regular, low (metronomic) dosing being used in an effort to maximise the anti-angiogenic action and maintain the anti-tumour activity (Vacca et al, 1999; Hanahan et al, 2000; Bertolini et al, 2003).
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"Dosing is by trial and error," Dr. Jafri says.
But dosing is the tricky part.
Dosing was according to age.
Thus, high and frequent dosing is required.
dosing were calculated.
In small doses, being nice is harmless.
Radiation dose was documented.
A pediatric dose is smaller.
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CEO of Professional Science Editing for Scientists @ prosciediting.com