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Randomisation will be in blocks of 20 for each dosing band.
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Finally, Bayesian dose optimization offers a truly personalized dosage for each patient rather than forcing the individual into one of several potential dosing bands.
Assuming dose banding with 5% tolerance the proportion would be reduced to 14.5% for men and 2.4% for women.
Dose banding, whereby prescribed chemotherapy doses are rounded up or down to pre-determined standard doses, is a common practice including in the three centres studied.
Dose banding is almost invariably performed within a 5% tolerance limit and therefore does not result in a significant change to the administered dose.
Dose Banding.
This study compares dose banding with individual BSA dosing and fixed dose according to pharmacokinetic criteria.
Dose banding in this case may be based on 'bands' of predicted carboplatin clearance.
In particular, dose banding could represent an economic interest for chemotherapy compounding units.
Cutoff values for the BSA bands were inspired from a previous dose-banding methodology used by Pouliquen et al (2011).
The potential impact of using dose banding (DoseBAND) or fixed dose (DoseFIXED) was evaluated in three different ways.
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