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However, because IGlar is only approved for dosing at the same time each day, we considered such off-label use inappropriate and unlikely to be approved by local ethics committees and institutional review boards.
But the daily dosing, at the same time that it lowers feed needs, lowers drug effectiveness and produces antibiotic-resistant bacteria or "superbugs".
Changing the schedule to twice weekly dosing at the same infusion rate reduces the dose per administration by an order of magnitude.
Similar(57)
Distinct differences in the retention of cobalt, zinc and copper were observed during the entire experiment, even when these metals were dosed at the same concentration (Table 1).
Patients in the placebo group received an equal number of tablets, dosed at the same time of day as for the test compound and all containing placebo.
With no lethality or toxicity signs or symptoms noted, two additional rats were dosed at the same 5000 mg/kg level with similar outcomes.
Rituximab dosed at the same single chain concentration showed variable induction of apoptosis in CD20+ cell lines with Raji cells responding better than SU-DHL-7 cells.
(Table 2) In five of the nine patients who were dosed at the same level on both day 4 and day 25, there was an average increase in drug clearance of 22%.
Perhaps government- or industry-supported training could address issues like diagnosis, injection procedures and dosing practices at the same time as advising on sourcing genuine products.
It is then possible to switch to rivaroxaban by giving the first dose at the same time that the next dose of LMWH or fondaparinux is scheduled [5].
At 21 days after the first immunization, all the animals were boosted with an identical dose at the same injection sites.
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CEO of Professional Science Editing for Scientists @ prosciediting.com