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Other trials of gels at different formulations and dosing are planned or under way.
Additional pharmacogenetic trials of warfarin dosing are currently underway (NCT00927862).
Four parameter pH, contact time, initial concentration and dosing are optimized by response surface methodology.
Issues related to the definition of a therapeutic window for LRRK2 inhibition and the safety of chronic dosing are discussed.
This effect may be true but alternative explanations such as optimal dosing are also possible and further study on this issue is needed.
Specifically data on pharmacokinetic and pharmacodynamic correlations and effect of pharmacokinetically guided, individualized dosing are important for the design of optimal cancer chemotherapy for individual patients.
It is evident from this work that both duration and magnitude of BDNF dosing are of critical importance in achieving functional outcome.
This is because it encompasses 2-h PF, but extends the requirements such that no rescue medication and no headache recurrence between 2 and 24 h after dosing are allowed.
However subsequent studies showed that the efficacy of buprenorphine sublingual tablet or buprenorphine/naloxone sublingual tablet (Suboxone®) is equivalent to that of methadone when sufficient buprenorphine doses, rapid induction, and flexible dosing are used [22, 42, 43].
23, 52 Published data on appropriate NCG dosing are limited.
Details for animal dosing are described in the Supporting Information.
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