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Current dosing approaches for treating microbial infections ignore resistant subpopulations.
However, these studies have not defined whether altered dosing approaches are advantageous and which patient groups may benefit.
These new rules may mean that the present dosing approaches are more or less likely to achieve PK/PD targets [29].
Considering the rampant development of bacterial resistance, the exact role of altered dosing approaches to reduce the problem should be addressed.
Errors in sampling, which are common in PK/PD studies, may result in inaccurate and faulty assessments with regards to the apparent benefits of either dosing approaches.
To date, studies investigating the impact of various beta-lactams dosing approaches and their associated risk of bacterial resistance are scarce [72].
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The present work introduces a possible new therapeutic insulin administration dosing approach for T2DM patients.
Field tests of the proposed self-adaptive coagulant dosing approach demonstrated measurable coagulant dose reduction while maintaining robust UF operation even during periods of both mild and severe water quality degradation.
There are several benefits of a PK-guided dosing approach for sunitinib.
The above-mentioned conditions call for an altered dosing approach in critically ill patients compared with mild-to-moderately ill patients [ 12- 14].
However, this dosing approach may still result in under-exposure in children with low weight as was shown for some mAbs (i.e., infliximab) with linear PK when using an exponent for CL of less than 1.
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