Sentence examples for dosing animals from inspiring English sources

RAD001 and vehicle aliquots were thawed 10-30 min before dosing animals and unused portions were discarded.

At 10 mg kg−1 a similar reduction (87%, P<0.05) was detected to that resulting from dosing animals with 50 mg kg−1 of 2-MeOE2.

"Say you're dosing animals with a chemical where, historically, an effect has not been seen below a dose of ten milligrams per kilogram," Bus explains.

To improve the ability to detect environmental factors that may contribute to prostate cancer, the breakout group encouraged the NTP to consider dosing animals in the early postnatal period during prostate duct development and to search for rodent strains more sensitive to development of prostate cancer.

Although there are limitations to all methods of dosing animals, the flaws associated with gavage are so severe for some substances, especially those subjected to a large first-pass effect, that this route of exposure should be abandoned for the study of EDCs.

For instance, dosing animals 4-phenyl butyrate (PBA) to protect against ER stress has a strong glucose-lowering effect even under basal conditions (Ozcan et al., 2006) Overexpression of BiP in β-cells has been shown to protect against apoptosis and diabetes progression in db/db mice (Laybutt et al., 2007), and it would be interesting to examine the effects of chronic SD in this model.

Immunohistochemical staining of human IgG1 in sections of cortex was consistent with these results, illustrating relatively less intense immunostaining in N434A than H435A dosed animals.

ApoB siRNA dosed animals demonstrated significant reductions of hepatic ApoB mRNA and serum APOB protein, with a substantial lowering of plasma lipid levels without obvious signs of toxicity.

However, diphenyl phosphate (DPHP) and mono-isopropylphenyl phenyl phosphate (ip-PPP) were detected in urine from the dosed animals.

AFN-1252 was therapeutically effective, and the exposure (area under the concentration-time curve from 0 to 48 h [AUC(0-48)]) of AFN-1252 in the pouch fluid was comparable therapeuticallyeffectiveorandy dosed animals.

Dosed animals were sacrificed at 15 min after the end of the intravenous injection.