Fast neutrons have a higher RBE in tumour cells, but lack the physical dose advantages of charged particles; the latter proved disadvantageous in the clinic (Wambersie and Menzel, 1996).
Liquid formulations offer the advantage of dosing flexibility and ease of administration to young patients, but drug substances often show poor aqueous solubility.
In extending the use of a CVD polypill-based preventive strategy to other settings, policymakers should capitalise on its main strengths in terms of dosing convenience and potential advantage in terms of cost, by targeting its use in high-risk populations where the greatest gains can be achieved.
48 Continuous infusion showed no advantage over bolus dosing.
Background: Because lovastatin is efficiently extracted by the liver and because its administration in divided doses is associated with increased efficacy, an extended-release (ER) formulation may have the potential for a dose-sparing advantage relative to the immediate-release (IR) formulation in the treatment of hypercholesterolemia.
Whereas smaller biological entities may require more frequent dosing, potential advantages include improved tissue penetration that, in RA, might provide greater access to inflamed synovium.
Interestingly, 100 mg/kg of 2DG was effective in decreasing the number of blood vessels, and there was no dose-dependent advantage of 2DG treatment in this respect.
Thus, in view of the important advantages of dose banding in terms of production time gain and reduction of wastage, it is of primary importance to evaluate whether it can be shown to be no worse than BSA dosing.
Evening dosed nebivolol may confer some advantage over morning dosing in reducing prewaking systolic BP.
While the primary advantage of orally dosed formulations is ease of use, alternative delivery options such as transdermal delivery or polymeric micro/nanoparticle encapsulation for oral administration have shown promise in niacin reformulation.
