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Mixer agglomeration, in particular high shear wet granulation, is a unit operation typically used in the pharmaceutical industry to improve the flowability, the compressibility, the dosing accuracy during tableting or the content uniformity of a blend.
In view of the lack of suitable paediatric antiretroviral formulations on the market, a novel fixed dose combination (FDC) tablet containing 300 mg zidovudine (AZT) and 160 mg lamivudine (3TC) was developed to improve dosing accuracy and allow flexible drug dosing in function of the body weight of paediatric HIV patients as recommended by WHO.
A reduction in the likelihood of failed administration due to greater dosing accuracy.
Successful usage was quantitatively assessed through the calculation of dosing accuracy based on the volume of liquid medication emptied from the pouch.
Solid state formulations such as mini tabs have a limitation in that they still lack the dosing accuracy needed for dosing the very young patient less than 1 year of age where liquid formulations are preferred for ease of administration as well as accuracy of dosing since dosing in this group of patients is generally weight based and often results in fractional dosing.
New-generation pens will provide a reduction in injection force and dosing accuracy over a broad range of insulin doses.
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Dose accuracy of up to 2.21% was found.
When doing this work, it must perform the source dose trace to assure the dose accuracy.
Dose accuracy and in vitro drug release patterns were assessed using HPLC and pH change flow-through dissolution test.
Dr. Rachelle Bitton's article "Improving Thermal Dose Accuracy in MR guided Focused Ultrasound Surgery (MRgFUS): A Prior Baseline Method of Long Term Thermometry" is featured on the cover of the Journal of Magnetic Resonance Imaging.
The use of a HME based pharmaceutical filament preserved the linear relationship between the mass and printed volume and was utilized to digitally control the dose via an input from computer software with dose accuracy in the range of 91 95%.
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