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Calculators for gentamicin and vancomycin doses were implemented in the hospital as an Excel application on the hospital intranet.
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For those patients where carboplatin dose was modified, dose increases were implemented in 43% of patients (9/21) and dose reductions in 57% (12/21).
Dose reductions were implemented in three patients (in 1 case due to a concurrent increase in liver enzymes).
Appropriate dose interruptions/reductions were implemented in the event of specific toxicities, depending on their nature and intensity.
Docetaxel dose reductions were implemented in 18 patients (31%), most at 30/100 mg m−2 (9 of 16 patients), and were generally due to mild to moderate oedema, fatigue/asthaenia, or skin/nail disorders.
Based on observations from the Japanese trials [ 14, 24], proactive protocol-defined strategies including dose modification guidelines were implemented in the CAPACITY studies to minimize the incidence and severity of selected AEs (such as GI and skin-related AEs) and encourage patients to continue treatment.
Delays and/or modifications in dose were implemented for increases in liver function test levels ≥grade 2.
The immunization coverage (BCG, OPV3, DPT3 and measles) at the inception of the project was 43% [ 10] but rose rapidly to 78% after 2 years, and hepatitis B coverage (three doses) was implemented and reached 58% in 2000 [ 8].
Online dose calculators for these drugs were implemented in a London National Health Service hospital.
When education and environment were implemented in combination, the doses of both were lower than expected in an additive model.
Of these, 17 were then used for the basic validation model (e.g. weight/age check, dose/weight check), 13 were implemented in the intermediate level (e.g. identification of adverse effects from excipients) and 9 were incorporated at advanced level (e.g. reconciliation at discharge for patients at risk).
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CEO of Professional Science Editing for Scientists @ prosciediting.com