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The use of higher cisplatin doses was based on one small randomised trial involving 85 patients, that demonstrated a longer duration of response and a survival advantage for responders in the higher dose arm but overall survival was not reported (Gralla et al, 1981).
Thus the efficacy for those with one and two vaccine doses was based on subsequent routine effectiveness studies and efficacy for additional serotypes was assumed to be slightly lower than the efficacy of the 3 dose series based on observational studies of the effectiveness of RV5 [ 25].
The choice of immunosuppressive drug doses was based on earlier studies [ 36, 37].
Selection of the extract doses was based on previous studies [ 4, 8, 9] on rats using herbal extracts.
The choice of the tramadol doses was based on Grond & Sablotzki (2004) [ 29], who noted that the potency was approximately 10% of that of morphine.
The rationale of these low and high doses was based on the literature reviews that each antioxidant and anti-inflammatory action was indicated by different optimal doses.
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Doses were based on the free base (290.49 g/mol; 65.95% of total molecular weight).
These doses were based on two previous studies from the same group with a goal of zero twitch for everyone during 48 h [29, 30].
Smaller doses are based on these standards, e.g., 75-mg and 81-mg tablets.
The doses were based on previous literature in rats [18] and mice [24].
All doses were based on previous studies.
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