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AMS reduces radiation exposure doses to levels safe for use in human volunteers of all ages.
Targeted gold nanoparticles (GNPs), due to their physical, radiation, and pharmacokinetic properties, are well suited to BT applications with the potential to boost local radiation doses to levels unimaginable with EBRT or conventional BT alone (Ngawa et al. 2013; Lechtman et al. 2013; Arnida and Ghandehari 2010; Babaei and Ganjalikhani 2014).
All of these strategies have involved the systemic administration of drugs or other agents that have specific toxicities of their own, which almost always limits pharmacological doses to levels below what is needed to sensitize tumors.
For WF, the ability to escalate doses to levels approaching an MTD to assess the presence and safety of unintended changes is limited by the bulk and complexity of the test material.
[ Based on high and moderate quality randomised controlled trials and the GDG's opinion] If they have achieved sustained and satisfactory levels of disease control with a combination of disease modifying antirheumatic drugs, cautiously try to reduce doses to levels that still maintain disease control.
In light of these findings, our group and other research groups pursued strategies to increase the efficiency of AAV factor IX gene delivery in hopes of achieving clinically meaningful expression while limiting vector doses to levels that are lower than the doses associated with apparent CTL-mediated immune response.
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The low-dose imaging strategies were illustrated effective for reducing the radiation dose to levels appropriate for live animal imaging.
The three-dimensional conformal radiotherapy (3D-CRT) approach has permitted significant increases in the tumor dose to levels beyond those feasible with conventional techniques.
Intra-patient dose escalation was allowed to dose levels shown to be safe and tolerable.
So what are the costs of regulating radiation doses to such absurdly low levels?
Absolute neutrophil counts at dose level 2 (dose intensity 3.0 mg m−2) were comparable to dose levels 5 and 6 (dose intensities 3.0 and 3.6 mg m−2, respectively).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com