In view of the doses of the components consumed, HZJW was extrapolated to offer a wide margin of safety by oral route.
Furthermore, the strength of interactive effects may differ as a function of the doses of the components depending on any nonlinearities in the dose response relationships for the biological processes affected by the components.
Indeed, in most patients for which blood pressure targets are difficult to achieve the use of multidrug combinations will often produce greater blood pressure reduction at lower doses of the component agents, resulting in fewer adverse events [ 47, 48].
The average dose of the components as calculated after analyses was as follows: daidzein - 14.1 mg/g sample, genistein - 8.6 mg/g sample, formononetin - 5 mg/g sample.
In spite of the fact that Algopirin® contains lower doses of active components, its effect on pain curves in migraine is superior to Excedrin®.
Daily doses of all components of the preparation were set below the human upper safe level [ 39].
Moreover, when exposures are to complex mixtures of chemicals, varying with time in number of components, doses of individual components, and constancy of exposure, the picture becomes even more complicated.
The difference of activity when a large excess of the Hex and EA extracts was added to the assay system, could be explained by the inhibition of the penetration through the cell membrane at high doses of extract components [ 27].
An evaluation of the pathophysiology of cigarette smoke and CVD suggests that underlying biochemical and cellular processes may become saturated with small doses of toxic components (Ambrose and Barua 2004).
It is, however, reassuring that at these lower doses of supplementation, most components of the innate and adaptive immune response were not affected over the long term.
