In view of the doses of the components consumed, HZJW was extrapolated to offer a wide margin of safety by oral route.
Furthermore, the strength of interactive effects may differ as a function of the doses of the components depending on any nonlinearities in the dose response relationships for the biological processes affected by the components.
The average dose of the components as calculated after analyses was as follows: daidzein - 14.1 mg/g sample, genistein - 8.6 mg/g sample, formononetin - 5 mg/g sample.
This study was conducted to compare the effects of two contraceptive pills with different doses of the same components, on plasma androgen levels and female sexual function among women without previous sexual dysfunction.
Note that the doses of the mixture components (e.g., PCBs only) were identical to the dose contained in the complete Arctic mixture.
This included determining the doses of the HEC/MEC components in order to pinpoint the specific regimen.
Some of the safety worries reflected previous experience with higher doses of the individual components of Qsymia rather than direct evidence of harm from trial data, although some signals were present at the 15/92 dose, including elevated heart rate and depression.
Pancreatic enzyme supplementation was expressed as total daily dose of the lipase component and as daily dose per kilogram of body weight.
This review also confirms that SHBG significantly increases during COC use, an effect which varied depending on the dose of the EE component.
That is, in a combination of c (here, c = 11) chemicals, E i represents the concentration or dose of the ith component alone that yields a fixed response (i.e., ED30), and x i represents the concentration/dose of the ith component in combination with the c agents that yield the same response.
