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Combining these micronutrients expands metabolic targets maximizing the biological impact with lower doses of components by nutrient synergy.
Furthermore, effective lower doses of components using nutrient synergy also assure overcoming absorption barriers characteristic for high vitamin doses.
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This study investigated the effect of maternal dexamethasone treatment, at clinically relevant doses, on components of the renin-angiotensin system (RAS) in the pregnant ewe and fetus.
Grimshaw et al. observed that an increase in dose of "component interventions" did not always lead to an increased response and proposed that multi-faceted interventions should be "built upon a careful assessment of barriers and a coherent theoretical base" [ 27].
Furthermore, the strength of interactive effects may differ as a function of the doses of the components depending on any nonlinearities in the dose response relationships for the biological processes affected by the components.
However, implantation doses of these components are not uniform in a conventional PIIID process.
In spite of the fact that Algopirin® contains lower doses of active components, its effect on pain curves in migraine is superior to Excedrin®.
Daily doses of all components of the preparation were set below the human upper safe level [ 39].
In view of the doses of the components consumed, HZJW was extrapolated to offer a wide margin of safety by oral route.
The difference of activity when a large excess of the Hex and EA extracts was added to the assay system, could be explained by the inhibition of the penetration through the cell membrane at high doses of extract components [ 27].
An evaluation of the pathophysiology of cigarette smoke and CVD suggests that underlying biochemical and cellular processes may become saturated with small doses of toxic components (Ambrose and Barua 2004).
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