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The following data available for meta-analysis were extracted: first author; country and year of publication; number and characteristics of patients; doses, concentration, and administration method of bupivacaine; epinephrine use and tourniquet use; type of anesthesia and surgery; study design; and outcomes.
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The doses, concentrations, and specific dose limits for the neonatal population were also updated in the drug library.
At equivalent S-DM1 dose concentration.
Lower concentrations were achieved by serial dilution from the high dose concentration.
97.5 % arsenic was removed at coated sand dose concentration of 5 g/100 ml.
Aliquots (100 μL) of the appropriate SPA concentrations were dispensed to create eight replicates of each dose concentration.
The newly synthesized compounds were evaluated against 60 human tumor cell lines at one dose and five dose concentration levels.
The synthesized compound 1 was tested initially at a single dose concentration of 10 μM over 45 different kinases.
In these instances, the dose (concentration)- response curve is linear (i.e. non-thresholded) and the concept of TTC may be applied for risk assessment.
Numerous studies based on in vivo and in vitro study confirmed that GTE and their constituents show health-promoting protective effect at a certain dose concentration [61].
For drugs with an indirect (non-DNA) genotoxic mechanism, a non-linear genotoxic effect to dose (concentration) curve is typical, allowing the identification of a NOGEL.
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