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It breaks down rapidly and, in the very low doses at which it is prescribed, should not pose a risk to humans.
By contrast, acetyl-LDL does not inhibit these genes at the doses at which oxidized-LDL is effective.
The actual number is probably higher because the clinical doses at which drugs are studied often saturate the target mediated elimination pathway, thereby masking the nonlinear PK.
This, however, occurred rather slowly, because the QDs were found to be nontoxic after their injection at the doses at which pure cadmium ions would have had a lethal effect.
And the drug's safety record during clinical trials — particularly at high doses, at which it's most effective — will clearly raise questions about how it would affect a broad population of overweight and obese patients, if it's approved for broad use.
Follow-up time after doses at which parasitaemia was not determined was excluded from this analysis.
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The dose at which ultimate mechanical properties decreased was at 200 kGy.
affected the lowest dose at which the rats first acquired methamphetamine self-administration (0.015 mg/kg/infusion).
The threshold dose at which dexamethasone was able to be used with minimal interference on these treatments was 4.1 mg per day or lower.
S began the Lexical Salience Task 90 min after dosing, at which time the subjective behavioral effects of oral AMPH are maximal (Brauer et al, 1996).
Thus, in all cancer cells tested high radiation doses induce the upregulation of Trex1, but the threshold dose at which it is sufficient to clear the cytosolic dsDNA varies in different cells between 12 and 18 Gy.
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