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The starting dose for allopurinol-naïve patients was 100 mg daily (some patients were on higher doses at the time of referral).
The relatively higher dose of paracetamol used in this study to prevent fever was due to the lack of availability of suppositories in smaller doses at the time of the study, limiting weight-adjusted dosing.
As described elsewhere [ 13, 14, 16, 17, 19– 21], we used criteria based on the number of missed doses at the time of evaluation (current) or between initiation of cART and the time of evaluation (cumulative).
The pharmacokinetic analysis was also repeated in patients who received more than five or six doses at the time of sampling in order to make sure that the assumption of steady state is valid.
Most of the children had received all age-appropriate scheduled PCV7 vaccinations at their URI visit, 666 (69%) of samples were collected from children who had received the age-appropriate number of PCV7 doses at the time of swab collection.
The total cumulative doses at the time of sampling for each endpoint were 0.9 cGy for 1 week, 1.8 cGy for 2 weeks, 2.7 cGy for 3 weeks, 3.6 cGy for 4 weeks, 4.5 cGy for 5 weeks and 5.4 cGy for 6 weeks of culture.
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Patients on Pravachol, or pravastatin, were given half that dose, 40 milligrams a day, because that was the maximum allowable dose at the time.
"Giving radiotherapy in a single dose at the time of surgery potentially offers a huge benefit, especially if it means fewer visits to hospital.
The OV was introduced into the rumen as a pulse dose at the time of feeding, thus most likely having larger effect on methane production during the period when methane data were collected.
To further examine this question, we estimated the role of exogenous insulin by correlating insulin infusion dose at the time of the biopsy with Akt phosphorylated at T308, our most upstream target.
To estimate the role of exogenous insulin in the activation of the Akt-mTOR-S6k pathway, we correlated the insulin infusion dose at the time of the biopsy with phosphorylation of Akt at T308, which represents the upstream activation by 3-phosphoinositide dependent protein kinase 1 (PDK1).
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