Exact(3)
and maintained with supplemental doses as required (4% w/v, 120 mg/kg i.p).
Extracellular single-neuron recordings were made in chloral hydrate-anesthetized (4 g/kg initial dose, i.p., with supplemental doses as required) male Wistar rats weighing between 350 450 g.
Postoperative analgesia consisted of a bolus of piritramide (0.1 mg/kg) on discontinuation of the remifentanil infusion, followed by bolus doses as required in 2 to 4 mg aliquots, plus regular paracetamol (1 g every six hours).
Similar(57)
Non-recovery: Anesthesia was provided by ketamine 10 mg/ml (Vetalar, Boehringer Ingelheim, Bracknell, UK), xylazine 2 mg/ml (Rompun, Bayer, Newbury, UK) and atropine 0.06 mg/ml (Sigma) at 0.1 ml/10 g and 0.1 ml doses thereafter as required.
Repeated dose interruptions were allowed as required, for a maximum of 14 days on each occasion.
There was also no effect of steam (table 3) and no effect of advice on regular compared with as required dosing (see appendix table A), and the per protocol analysis produced similar results.
The following were recorded: drugs used regularly or as required, drug doses, laboratory data (such as creatinine clearance and electrolytes), blood pressure and number of visits or re-admissions to hospital after discharge.
"Instead of the one dose as required under the protocol, ADC injected 15 separate doses of the drug combination, resulting in the most prolonged execution in recent memory.
Anesthesia was maintained with further doses of Hypnorm (1/3 original dose) as required.
Patients received either 2.4 mg (44 patients) or 4.8 mg (7 patients) of rFVIIa, with a second dose as required.
In addition, patients may be less reluctant to use an inhalative system upon exposure to an allergen prior to the development of symptoms and may continue or repeat dosing as required.
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