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Research into pharmacokinetics, efficacy, and adverse effect profiles of bilastine in children under 12 years of age is needed as are dose-response assessments and studies planned rigorously with the aim of assessing quality of life effects.
Research into aspects of pharmacokinetics and efficacy and adverse effect profiles of bilastine in children under 12 years of age is needed as are dose-response assessments and studies planned rigorously with the aim of assessing quality of life effects.
Opportunities include: identifying and characterizing toxicity pathways; informing the conditions and limits of extrapolation; addressing issues of susceptibility and variability; providing reality-checks on selected positives and negatives from screens; and performing targeted testing and dose-response assessments of chemicals flagged during screening.
It consolidates exposure, hazard and dose-response assessments into a single risk forecast.
Both exposure potential and dose-response assessments are incorporated in the BNs to generate a quantitative forecast of risk with parameterization (Fig. 2).
Risk assessments from exposure to indoor air pollutants require exposure assessments and dose-response assessments.
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The purpose of this paper is to describe current dose-response assessment methods applicable to assessing risk following exposure to indoor air pollutants.
The site and intensity of musculoskeletal discomfort was assessed before and after schoolbag carriage to provide a dose-response assessment of schoolbag-related discomfort for the first time.
In this respect, biomonitoring data are increasingly becoming a primary basis for hazard identification as well as dose-response assessment.
Two distinct dose-response assessment models have been tested for carcinogenic (linear model) and non-carcinogenic (threshold model) toxicants [41, 50] via the OEL and are directly parameterized by its parent node CMR.
For chemical agents, a dose-response assessment should be performed.
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