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This is where dosimetry, or more specifically the tools used to define dose, will have significant value.
"If someone's tiny, a much smaller dose will have a similar effect.
Suggested final oral dose will have to achieve plasma levels of 0.4 to 1.0 mmol/L.
If two doses protect for more than 20 years, then the third dose will have to be priced substantially lower (median threshold price £31, interquartile range £28-£35 £28-£35costoeffective.
This concept is based on the theory that the same dose will have less effect if there is less need for it, and is defined as a " curvilinear dose response association".
The initial dose will have been chosen on the basis of the doses used in the phase 1 studies, which in turn will have been extrapolated from animal and in vitro studies.
Similar(52)
In general, repeated doses will have progressively greater effect and, in addition to extending the duration of surgical anaesthesia, can prolong the sleeping/recovery time following anaesthesia.
Also issues regarding radiation doses will have to be taken into account [ 142, 143, 181, 182].
Whilst these may be equipotent doses in the management of hypercholesterolaemia, it remains unknown what effects these agents at these doses will have in acute lung injury.
This increased variability can be explained partly by the children dosed with the lowest oral doses, because such doses will have a greater proportion of short-chain MTXPGs that are susceptible to more significant and rapid concentration shifts.
While under dosing will have less of an effect on the bacterial infection you are trying to fight, overdosing can increase the potency of the drug, making it much more likely that you will have an upset stomach.
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CEO of Professional Science Editing for Scientists @ prosciediting.com