A short cluster up-dosing schedule of only 1 week was applied to achieve the maintenance dose which was administered monthly during the study period of 1 year.
I was vaccinated as a child, but with only one dose, which was standard at the time.
An intravenous pretreatment with PEGylated liposomes produced a striking change in the biodistribution of the second dose which was given several days after the first injection.
However, the α phase was "flipped-flopped" due to relatively slow dermal penetration and rapid elimination of the systemically absorbed dose, which was corrected to ∼0.3 h after separating α elimination phase from the absorption.
Enthusiasm was dampened when it emerged that the benefit was seen in those on the highest dose, which was also associated with serious side effects, including swelling of the brain.
Of the 11 who received the drug for the entire 36 months, those who got the optimal dose — which was a high dose — for the whole time fared the best.
PDMS containing heterogeneously distributed, aggregated filler particles (Sylgard 170), exhibited an increasing surface roughness with treatment dose, which was attributed to the "collapse" of the oxidized surface region thus exposing the contours of the underlying filler aggregates (final surface roughness ∼140 nm).
The interactions between the factors were antagonistic (Fig. 9a e), except that manifested between temperature and clay dose, which was synergetic (Fig. 9f).
No correlation between ∆D90 and tumor volume was observed (ρ = 0.14, P = 0.62), likely secondary to the sensitivity of D90 to the 10% of tumor volume receiving the lowest dose, which was effected by adjuvant ablation regardless of tumor size.
Lopez-Rodriguez and co-authors had measured the residence time in the choroid plexuses but did not provide an estimation of the absorbed dose, which was probably due to the difficulty of defining an actual volume for this organ [35].
Table 4 lists the dose which was found to be optimum to clear out each resist as well as the resist dimensions and exemplary optical micrographs of each exposure.
