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In the "maintenance" experiments, CGP7930 and GS39783 reduced daily alcohol intake by 30 40% only at the highest dose when compared to vehicle-treated rats; this effect tended to vanish on continuing treatment.
For the i-CAT machine used in our study, the use of the 13 cm FOV scan results in 50% reduction of the overall radiation dose when compared to the 22 cm scan [9].
Knockdown of VDR dramatically reduced cell proliferation in both HaCaT and HaCaT II-4 cells, regardless of VD3 dose when compared to control siRNA-transfected cells.
Owing to the patient's weight (80 kg) at the time of admission, 500 mg of azithromycin [ 13], which was 6.25 mg/kg, might have been an inadequate dose when compared to previously recommended doses.
However, in a Phase I study with COL-3, changes in plasma MMP-2 were significantly related to dose when compared to patients with progressive disease vs those with stable disease (Rudek et al, 2001).
Results clearly illustrate that Titanocene Y is as effective as cisplatin at reducing tumour cell growth in vivo at their respective maximum tolerable dose, when compared to solvent-treated animals.
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Afucosylated therapeutic antibodies with enhanced ADCC activity have been reported to possess greater efficacy in tumor growth inhibition at lower doses when compared to fucosylated therapeutic antibodies.
Compound 4f showed the highest anti-inflammatory activity (% edema inhibition = 15 20%) at all doses when compared to reference drug celecoxib (% edema inhibition = 15.7 17.5%).
Also, please note that the experiments in current Figure 4 figure supplement 3 applied lower irradiation doses when compared to original Figure 3A (now Figure 4B).
Cohen & Arnold (2011) note that DNA-reactive carcinogens produce "strikingly non-linear dose response" curves, due in part to an acceleration of damage, or lack of repair at higher doses when compared to lower doses.
The mean level of creatinine for all the drug doses was found to be similar with a small but insignificant increase in urea levels at 7.5 mg/kg single and double doses when compared to untreated controls.
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