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Hence when the immunization dose was raised to 104 or 105, the mice showed 100% survival.
Her tacrolimus dose was raised to 2 mg twice daily, with a goal of maintaining serum levels of 7 8 ng/mL.
Six of the eight rats tested showed impairment in delayed alternation performance as the dose was raised (1.5 3 mg/kg, especially following 2 3 mg/kg).
Indeed, the only change was a significant increase at 1 mg/kg that was lost when the dose was raised to 2 mg/kg.
When the adolescent dose was raised to 6 mg/kg, the immune reaction in this population was reduced by approximately a factor of four.
When this turned out not to be an issue, the infectious dose was raised to 10 CFU to increase lung infection levels, yield more countable colonies, and allow the effects of a range of infectious doses to be examined.
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Staskal and co-workers have also demonstrated that the pharmacokinetic behavior of BDE-47 is dose dependent, with relative elimination decreasing as the dose is raised.
On the other hand, the possibility of suboptimal dosing could not be unthinkingly discounted since some patients do respond when the dose is raised to the maximum.
If the endometrial thickness is less than 8 mm, the progynova dose is raised to 2 mg 4 times daily for 7 days.
First, a small degree of cholinergic stimulation can be promotional for neural cell differentiation because of the neurotrophic role of acetylcholine (Lauder and Schambra 1999), whereas that effect would likely be offset when the dose is raised closer to the threshold for systemic toxicity (Qiao et al. 2002).
Alternatively, the ability of the organophosphates and their oxons to bind to the m2AChR and interfere with its function (Howard and Pope 2002; Huff et al. 1994) would be likely to elicit compensatory up-regulation of receptor expression, which would then be offset by down-regulation consequent to cholinesterase inhibition as the dose is raised.
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