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For stimulus, a 10 µl aliquot of a test compound in the desired dose was loaded on a filter paper strip, the solvent was evaporated for 30 s, and the strip was placed in a disposable plastic syringe from which air was delivered to the preparations.
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The 1 Dose group was loaded (0.5 to 2 MPa at 0.1 Hz for 2 hours) on day 1 and on successive days placed in the water bath for 2 hours along with the Control group; the Daily loading group was loaded daily (0.5 to 2 MPa at 0.1 Hz for 2 hours) for eight days.
This would have the added advantage of enabling a variety of different doses or different drugs to be loaded in the implant for use in the treatment of various diseases.
In the first phase, a 60-mg prasugrel loading dose was compared with a 600-mg loading dose of clopidogrel.
Median simulated concentrations of vancomycin at the end of the loading dose was 20.4 mg/L (17.1 23.7), showing that the loading dose was appropriate to reach the target of 15 25 mg/L [WU3].
If dose-limiting events (DLEs) occurred (as described below) during administration of the loading dose, the loading dose was stopped.
Throughout the period considered by our study, the protocol set a weight-based loading dose of 1000 mg for patients with a body weight <65 Kg, and 1500 mg for patients with a body weight >65 Kg [ 5], diluted in a 100 ml of saline solution and administered over 60 minutes when the loading dose was 1000 mg; and over 90 min when the loading dose was 1500 mg.
The mean loading dose was 1072±359 mg, consistent with the mean body weight (72.7±14.5 kg) and French guidelines (quinine loading dose, 16 mg/kg) [9].
The loading dose was equivalent to the maintenance dose, except for a shorter time interval between loading doses than between subsequent maintenance doses.
Four studies and one sub-study of PCI intervention had a 300 mg loading dose of clopidogrel as pretreatment, 6 18262930 30 one study had a 600 mg loading dose, 25 and in one substudy the clopidogrel loading dose was left to the discretion of the investigators but was ≥300 mg in all cases.
The average loading dose was 6.3 mg/kg body weight, and 50% of patients required a continuous infusion.
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